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Table 3 Multivariate Analysis of Prognostic factors of BCSS and OS in Metastatic Breast Cancer

From: The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer

Characteristic

BCSS

OS

HR

95%CI

p

HR

95%CI

p

Age

1.01

1.008–1.013

< 0.001

1.018

1.016–1.020

< 0.001

Race

 White

1

  

1

  

 Black

1.074

0.985–1.171

0.104

1.262

1.171–1.360

< 0.001

 Others

0.932

0.819–1.061

0.286

1.011

0.902–1.133

0.85

Marital status

 Married

1

  

1

  

 Unmarried

1.1

1.026–1.178

0.007

1.244

1.172–1.320

< 0.001

Grade

 I

1

  

1

  

 II

1.199

1.031–1.396

0.0019

1.353

1.197–1.530

< 0.001

 III & IV

1.372

1.177–1.599

< 0.001

1.803

1.590–2.043

< 0.001

BC Subtype

 HR+/HER2-

1

  

1

  

 HR+/HER2+

1.084

0.979–1.201

0.12

0.876

0.800–0.959

0.004

 HR−/HER2+

1.363

1.196–1.553

< 0.001

1.15

1.026–1.289

0.017

 Triple negative

2.12

1.925–2.335

< 0.001

2.823

2.596–3.069

< 0.001

Stage T

 T0/T1

1

  

1

  

 T2

1.019

0.906–1.147

0.748

0.997

0.908–1.094

0.948

 T3

1.048

0.921–1.191

0.478

1.053

0.948–1.170

0.332

 T4

1.189

1.059–1.334

0.003

1.227

1.118–1.348

< 0.001

Stage N

 N0

1

  

1

  

 N1

0.923

0.841–1.014

0.095

0.926

0.856–1.001

0.054

 N2

0.863

0.761–0.978

0.021

1.072

0.962–1.194

0.208

 N3

0.929

0.844–1.023

0.136

1.064

0.980–1.154

0.138

Surgery

 No

1

  

1

  

 Yes

0.733

0.680–0.790

< 0.001

0.595

0.558–0.634

< 0.001

Radiotherapy

 No

1

  

1

  

 Yes

0.898

0.837–0.964

0.003

0.981

0.922–1.042

0.528

Chemotherapy

 No/Unknown

1

  

1

  

 Yes

0.685

0.634–0.741

< 0.001

0.682

0.638–0.730

< 0.001

Metastatic site

 Bone

1

  

1

  

 Lung

0.994

0.881–1.122

0.921

0.994

0.897–1.100

0.902

 Liver

1.384

1.208–1.586

< 0.001

1.428

1.272–1.602

< 0.001

 Brain

1.975

1.551–2.514

< 0.001

2.307

1.862–2.859

< 0.001

 Other

0.955

0.827–1.103

0.532

1.127

1.001–1.269

0.048

 Multiple

1.475

1.361–1.599

< 0.001

1.806

1.684–1.937

< 0.001

  1. Abbreviations: BCSS breast cancer–specific survival, OS overall survival, HR hazard ratio, CI confidence interval, BC breast cancer, HR hormone receptor, HER2 human epidermal growth receptor 2, TN triple negative
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BMC Cancer

ISSN: 1471-2407

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