Fig. 3From: Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cellsEffect of VAF cut-off on TP53 mutation prevalence detected in AEC of subjects with or without cancer. Hotspot regions in TP53 exons 5, 6, and 7 were targeted. Variants were binned according to VAF lower limit and cumulative variants in cancer (solid symbol) or non-cancer subjects (open symbol) above the indicated VAF threshold were plottedBack to article page