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Fig. 5 | BMC Cancer

Fig. 5

From: Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells

Fig. 5

Inter-cohort comparison of EGFR mutation mean prevalence. a Mean mutation prevalence among subjects within each cohort in each EGFR exon [18,19,20,21], or (mutations/target base/subject). b Cohort- and substitution-specific mean mutation prevalence for the combined four EGFR exon targets. c Number of mutations at EGFR hotspot sites. Inset: number of mutations according to mutation type. Mutations were defined as those with VAF (variant allele reads/total allele reads) > 5 × 10− 4 (0.05%) and significantly above IS background VAF based on contingency table analysis (see Methods)

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BMC Cancer

ISSN: 1471-2407

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