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Table 2 Target- and cohort-specific mutation prevalence

From: Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells

Target

CA-SMK

NC-SMK

NC-NON

NC-TOT

Average (All Subjects)

BRAF_15

6.7 × 10− 3

0

0

0

3.9 × 10− 3

EGFR_18

0

0

0

0

0

EGFR_19

0

0

0

0

0

EGFR_20

3.9 × 10−2

3.4 × 10− 2

4.5 × 10− 2

3.8 × 10− 2

3.8 × 10− 2

EGFR_21

1.7 × 10− 3

0

0

0

9.9 × 10− 4

ERBB2

1.1 × 10− 2

1.4 × 10− 2

1.4 × 10− 2

1.4 × 10− 2

1.2 × 10− 2

KRAS_2

0

0

0

0

0

PIK3CA_10

4.2 × 10− 3

0

0

0

2.4 × 10− 3

TP53_5

2.2 × 10− 2

4.7 × 10− 3

0

2.9 × 10− 3

1.4 × 10− 2

TP53_6

2.2 × 10− 2

0

3.1 × 10− 3

1.2 × 10− 3

1.3 × 10− 2

TP53_7

1.3 × 10− 2

2.9 × 10− 3

0

1.8 × 10− 3

8.5 × 10− 3

Average (All Targets)

1.2 × 10− 2

4.7 × 10− 3

5.3 × 10− 3

4.9 × 10− 3

8.9 × 10− 3

  1. Mutations were defined as substitutions with VAF (variant allele reads/total allele reads) > 5 × 10− 4 and significantly above IS VAF (i.e., background noise) based on contingency table analysis. Mutation prevalence was defined as mutations/target bp/subject (see Methods)