From: DNA methylation of SFRP1, SFRP2, and WIF1 and prognosis of postoperative colorectal cancer patients
Characteristics | Total | SFRP1 N (%) | SFRP2 N (%) | WIF1 N (%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
N | Hypo-M a | Hyper-M b | P value | Hypo-M | Hyper-M | P value | Hypo-M | Hyper-M | P value | |
All cases | 307 | 55 (17.9) | 252 (82.1) | Â | 264 (86.0) | 43 (14.0) | Â | 224 (73.3) | 83 (26.7) | Â |
Age | Â | Â | Â | 0.040 | Â | Â | 0.382 | Â | Â | 0.459 |
  < 45 years-old | 33 | 7 (12.7) | 26 (10.3) |  | 26 (9.8) | 7 (16.3) |  | 27 (12.1) | 6 (7.2) |  |
 45~60 years-old | 132 | 31 (56.4) | 101 (40.1) |  | 113 (42.8) | 19 (44.2) |  | 96 (42.9) | 36 (43.4) |  |
  ≥ 60 years-old | 142 | 17 (30.9) | 125 (49.6) |  | 125 (47.4) | 17 (39.5) |  | 101 (45.0) | 41 (49.4) |  |
Gender | Â | Â | Â | 0.766 | Â | Â | 0.944 | Â | Â | 0.224 |
 Male | 180 | 33 (60.0) | 147 (58.3) |  | 155 (58.7) | 25 (58.1) |  | 136 (60.7) | 44 (53.0) |  |
 Female | 127 | 22 (40.0) | 105 (41.7) |  | 109 (41.4) | 18 (41.9) |  | 88 (39.3) | 39 (47.0) |  |
CEA | Â | Â | Â | 0.930 | Â | Â | 0.207 | Â | Â | 0.824 |
  < 5 ng/mL | 130 | 23 (41.8) | 107 (42.5) |  | 108 (40.9) | 22 (51.2) |  | 94 (42.0) | 36 (43.4) |  |
  ≥ 5 ng/mL | 177 | 32 (58.2) | 145 (57.5) |  | 156 (59.1) | 21 (48.8) |  | 130 (58.0) | 47 (56.6) |  |
CA19–9 |  |  |  | 0.114 |  |  | 0.180 |  |  | 0.327 |
  < 37 U/mL | 232 | 37 (67.3) | 195 (77.4) |  | 196 (74.2) | 36 (83.7) |  | 166 (74.1) | 66 (79.5) |  |
  ≥ 37 U/mL | 75 | 18 (32.7) | 57 (22.6) |  | 68 (25.8) | 7 (16.3) |  | 58 (25.9) | 17 (20.5) |  |
Multiple polyps | Â | Â | Â | 0.600 | Â | Â | 0.127 | Â | Â | 0.115 |
 No | 220 | 41 (74.5) | 179 (71.0) |  | 185 (70.1) | 35 (81.4) |  | 155 (69.2) | 65 (78.3) |  |
 Yes | 87 | 14 (25.5) | 73 (29.0) |  | 79 (29.9) | 8 (18.6) |  | 69 (30.8) | 18 (21.7) |  |
Tumor location | Â | Â | Â | 0.424 | Â | Â | 0.326 | Â | Â | 0.809 |
 Colon | 115 | 18 (32.7) | 97 (38.5) |  | 96 (36.4) | 19 (44.2) |  | 83 (37.1) | 32 (38.6) |  |
 Rectum | 192 | 37 (67.3) | 155 (61.5) |  | 168 (63.6) | 24 (55.8) |  | 141 (62.9) | 51 (61.4) |  |
TNM Staging | Â | Â | Â | 0.121 | Â | Â | 0.042 | Â | Â | 0.311 |
 I- II | 163 | 24 (43.6) | 139 (55.2) |  | 134 (50.8) | 29 (67.4) |  | 115 (51.3) | 48 (57.8) |  |
 III-IV | 144 | 31 (56.4) | 113 (44.8) |  | 130 (49.2) | 14 (32.6) |  | 109 (48.7) | 35 (42.2) |  |
Tumor invasion | Â | Â | Â | 0.364 | Â | Â | 0.111 | Â | Â | 0.183 |
 T1- T3 | 151 | 24 (42.9) | 127 (50.4) |  | 125 (47.3) | 26 (60.5) |  | 105 (46.9) | 46 (55.4) |  |
 T4 | 156 | 31 (56.4) | 125 (49.6) |  | 139 (52.7) | 17 (39.5) |  | 119 (53.1) | 37 (44.6) |  |
Lymph nodes involved | Â | Â | Â | 0.036 | Â | Â | 0.056 | Â | Â | 0.403 |
 N0 | 173 | 24 (43.6) | 149 (59.1) |  | 143 (54.2) | 30 (69.8) |  | 123 (54.9) | 50 (60.2) |  |
 N1- N2 | 134 | 31 (56.4) | 103 (40.9) |  | 121 (45.8) | 13 (30.2) |  | 101 (45.1) | 33 (39.8) |  |
Metastasis status | Â | Â | Â | 0.231 | Â | Â | 0.165 | Â | Â | 0.384 |
 M0 | 284 | 53 (96.4) | 231 (91.7) |  | 242 (91.7) | 42 (97.7) |  | 209 (93.3) | 75 (90.4) |  |
 M1 | 23 | 2 (3.6) | 21 (8.3) |  | 22 (8.3) | 1 (2.3) |  | 15 (6.7) | 8 (9.6) |  |
Pathological classification | Â | Â | Â | 0.053 | Â | Â | 0.316 | Â | Â | 0.023 |
 Prominence | 199 | 31 (56.4) | 168 (66.7) |  | 168 (63.6) | 31 (72.1) |  | 135 (60.3) | 64 (77.1) |  |
 Ulceration | 86 | 16 (29.1) | 70 (27.8) |  | 78 (29.5) | 8 (18.6) |  | 71 (31.7) | 15 (18.1) |  |
 Others | 22 | 8 (14.5) | 14 (5.5) |  | 18 (6.9) | 4 (9.3) |  | 18 (8.0) | 4 (4.8) |  |
Histologic classification | Â | Â | Â | 0.044 | Â | Â | 0.113 | Â | Â | 0.361 |
 Adenocarcinoma | 235 | 35 (63.6) | 200 (79.4) |  | 203 (76.9) | 32 (74.4) |  | 176 (78.6) | 59 (71.1) |  |
 Mucinous adenocarcinoma | 68 | 19 (34.5) | 49 (19.4) |  | 59 (22.3) | 9 (20.9) |  | 45 (20.1) | 23 (27.7) |  |
 Others | 4 | 1 (1.9) | 3 (1.2) |  | 2 (0.8) | 2 (4.7) |  | 3 (1.3) | 1 (1.2) |  |
Differentiation degree | Â | Â | Â | 0.011 | Â | Â | 0.083 | Â | Â | 0.255 |
 Poor | 49 | 15 (27.3) | 34 (13.5) |  | 46 (17.4) | 3 (7.0) |  | 39 (17.4) | 10 (12.0) |  |
 Moderate or well | 258 | 40 (72.7) | 218 (86.5) |  | 218 (82.6) | 40 (93.0) |  | 185 (82.6) | 73 (88.0) |  |