Fig. 4
From: Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer
Gene sets enriched in single-locus survival and resistance acquisition signatures. Gene set enrichment analysis of single-locus survival (x-axis) and RA signatures (y-axis). a T47D TMX/LTED signature versus ER+/HER2− single-locus signature. b T47D TMX signature versus TAM single-locus signature. c T47D LTED signature versus AI single-locus signature. Each diamond represents either a Hallmark (H) gene set or a curated gene set (C: Creighton, M: Massarweh) related to tamoxifen treatment or ET from the Molecular Signatures Database. Gene sets significantly enriched (FDR < 0.1, that is -log10(FDR) > 1, indicated by the red dashed lines) in both signatures are labelled with their name. See Additional File 12 for a version of this figure in which more gene sets are labelled