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Table 3 Associations of MRS and Risk of CRC According to Age, Gender and Time-To-Diagnosis of Nested Case Control Study Based on EPIC-Italy Cohort

From: A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility

Characteristics

Entire Dataset

Training Dataset

Testing Dataset

OR

95% CI

P-value

OR

95% CI

P-value

OR

95% CI

P-value

Age

  < 60

2.35

1.95, 2.90

< 0.0001

2.62

2.06, 3.44

< 0.0001

1.97

1.44, 2.84

< 0.0001

  ≥ 60

2.60

1.77, 4.17

< 0.0001

2.87

1.77, 5.35

0.0002

2.28

1.20, 5.51

0.03

Gender

 Male

1.97

1.47, 2.71

< 0.0001

2.10

1.44, 3.21

0.0002

1.91

1.20, 3.37

0.02

 Female

2.64

2.12, 3.37

< 0.0001

2.96

2.26, 4.08

< 0.0001

2.08

1.46, 3.20

0.0002

Time-diagnosis

  < 6 years

2.21

1.80, 2.77

< 0.0001

2.40

1.86, 3.20

< 0.0001

1.99

1.40, 3.02

0.0004

  ≥ 6 years

2.51

2.01, 3.23

< 0.0001

2.88

2.17, 4.01

< 0.0001

1.97

1.36, 3.05

0.0008

  1. Abbreviations: CI Confidence interval, CRC Colorectal cancer, MRS Methylation risk score, OR Odds ratios adjusted for age and gender, P values < 0.05 are in bold
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BMC Cancer

ISSN: 1471-2407

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