Fig. 1From: Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathwaySNHG3 was upregulated in BC. a. Volcano map of lncRNAs between BC and benign breast lesions specimens by transcriptome analysis. The blue dots indicated high lncRNA expression; the red dots indicated low lncRNA expression and the black dots showed the lncRNAs with an expression of |log2FC| < 2. Log2FC was logarithm of fold-change with base 2 and the fold-change was cancer over normal. The Y axis represented an adjusted FDR, and the X axis represented the log2FC value. Aberrantly expressed lncRNAs were identified by DESeq R. Altogether, 137 highly expressed and 139 low expressed lncRNAs were identified; b. Different expressions of the top 8 lncRNAs between BC and benign breast lesions specimens by RT-qPCR; c. SNHG3 expression in normal tissue and primary tumor assessed by UALCAN; d. SNHG3 level among BC cell lines and human mammary epithelial cells detected using RT-qPCR. Three independent experiments were performed. Data are expressed as mean ± standard deviation; one-way ANOVA and Tukey’s multiple comparisons test was used, *p < 0.05, **p < 0.01Back to article page