Fig. 6

Distinct fusion patterns between DDLPS and LMS revealed by RNA-Seq. a-b Circos plot indicating genome-wide gene fusion events in LMS (a) and DDLPS (b). The lines link the partners of fusion. c Box plot of fusion events per sample in LMS and DDLPS. The median value is indicated by the line inside the box. The dots indicate the fusion counts in individual samples. d-e Electrophoresis traces of two example gene fusion events verified by RT-PCR in tandem with Sanger sequencing. The cerulean arrows indicate the position of fusion between the left- and right-side genes. AKR1E1-AKR1E2 is detected in LMS (d) and ATXN2-MYRFL is detected in (e). The identities of all the RNA-seq predicted and Sanger sequencing verified fusion events are listed in Supplementary Table S1