Fig. 3

Genes overlapping with external cohort. In the Venn diagram, we highlight the number of significant genes overlapping between our transcriptomic associations of proctitis (radiotoxicity phenotype) for prostate and whole-blood tissue and an external dataset with similar phenotype assessing differential expression between groups receiving untreated vs 2Gy of radiation. The overlap of 27 genes between whole-blood and external dataset is significant. 14/27 genes had same direction of expression in both datasets and were further analyzed for GSEA. The chord plot shows the representative Database: Name of function category on the right side of the circle and genes present in these categories are on the left connected with strings. The up/downregulation of genes is reported via their z-scores. See Supplementary file for details