Fig. 2
From: Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway
The pro-AAM potential of the HGSOC cell lines was not correlated with the secretion of established pro-AAM factors. a Gene expression (Z-score normalized) from HGSOC cell lines in co-culture compared to their pro-AAM potential (the resulting number of CD68+ and CD163+ cells after 7 days of co-culture). Values represent the average of 4 microdevices. b CD68+ per field of view and (c) 163+ cells per field of view after monocytes have been alternatively activated using MCSF, IL4, and IL13 (AAMs) or co-cultured with HGSOC cell lines OVCAR5 and OVCA432 for 7 days, +/− an anti-MCSF antibody. Data are expressed as average ± SD, n = 4 microdevices per condition; *p < 0.05 vs. Veh. by two-way ANOVA with Tukey multiple comparison correction. d Cytokine expression (Z-score normalized) from HGSOC cell lines in co-culture compared to their pro-AAM potential. Values represent the average of 4 microdevices