Risk factors, prognostic factors, and nomograms for bone metastasis in patients with newly diagnosed infiltrating duct carcinoma of the breast: a population-based study

Table 3 Univariate analysis of risk factor of bone metastasis in infiltrating duct carcinoma patients

Variable	Without bone metastasis number (n)	With bone metastasis number (n)	Chi-square	P-value
Age
22–54	48,587	851	1.447	0.148
55–79	79,820	1294
≥ 80	11,169	238
Race
Black	14,149	317	31.319	< 0.001
Other	13,418	187
White	112,009	1879
Sex
Female	138,542	2341	32.512	< 0.001
Male	1034	42
Primary Site
Nipple	466	13	148.540	< 0.001
Central portion of breast	7096	223
Upper-inner quadrant of breast	20,291	229
Lower-inner quadrant of breast	9111	156
Upper-outer quadrant of breast	54,561	865
Lower-outer quadrant of breast	11,913	184
Axillary tail of breast	717	19
Overlapping lesion of breast	35,421	694
Grade
I	30,963	156	354.137	< 0.001
II	58,535	1104
III	49,802	1118
IV	303	5
Laterality
Left - origin of primary	70,495	1247	3.113	0.078
Right - origin of primary	69,081	1136
T stage
T1	89,950	336	8220.550	< 0.001
T2	41,110	987
T3	5726	405
T4	2790	655
N stage
N0	98,517	557	3293.151	< 0.001
N1	31,716	1160
N2	6249	321
N3	3094	345
Brain metastasis
No	139,497	2260		< 0.001
Yes	79	123
Liver metastasis
No	139,099	1881	14,692.994	< 0.001
Yes	477	502
Lung metastasis
No	139,015	1811	16,483.956	< 0.001
Yes	561	572
Breast subtype
HR−/HER2-	17,493	238	168.712	< 0.001
HR−/HER2+	6733	167
HR+/HER2-	99,394	1525
HR+/HER2+	15,956	453
ER status
Negative	25,818	432	0.212	0.645
Positive	113,758	1951
PR status
Negative	39,323	765	17.850	< 0.001
Positive	100,253	1618
HER2 status
Negative	116,887	1763	162.697	< 0.001
Positive	22,689	620
Insurance
Uninsured	2575	126	148.772	< 0.001
Insured	137,001	2257
Marital status
Unmarried	52,029	1101	79.707	< 0.001
Married	87,547	1282

ISSN: 1471-2407