Table 4 Expression of cellular markers in normal cervix, SIL, and cervical cancer
NSIL | LSIL | HSIL | CC | ||||||
|---|---|---|---|---|---|---|---|---|---|
n = 79 | % | n = 208 | % | n = 35 | % | n = 42 | % | p | |
p16INK4a | |||||||||
Negative | 33 | 41.8 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | < 0.001 |
Mild | 29 | 36.7 | 7 | 3.4 | 1 | 2.9 | 0 | 0.0 | |
Moderate | 11 | 13.9 | 168 | 80.8 | 6 | 17.1 | 0 | 0.0 | |
Intense | 6 | 7.6 | 33 | 15.9 | 28 | 80.0 | 42 | 100 | |
Ki-67 | |||||||||
Negative | 33 | 41.8 | 2 | 1.0 | 0 | 0.0 | 0 | 0.0 | < 0.001 |
Mild | 28 | 35.4 | 26 | 12.5 | 2 | 5.7 | 0 | 0.0 | |
Moderate | 18 | 22.8 | 165 | 79.3 | 8 | 22.9 | 0 | 0.0 | |
Intense | 0 | 0.0 | 15 | 7.2 | 25 | 71.4 | 42 | 100 | |
Cyclin E | |||||||||
Negative | 36 | 45.6 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | < 0.001 |
Mild | 27 | 34.2 | 17 | 8.2 | 0 | 0.0 | 0 | 0.0 | |
Moderate | 13 | 16.4 | 170 | 81.7 | 14 | 40.0 | 0 | 0.0 | |
Intense | 3 | 3.8 | 20 | 9.6 | 21 | 60.0 | 42 | 100 | |
TOP2A/MCM2 | |||||||||
Negative | 42 | 53.2 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | < 0.001 |
Mild | 25 | 31.6 | 20 | 9.6 | 0 | 0.0 | 0 | 0.0 | |
Moderate | 11 | 13.9 | 179 | 86.1 | 11 | 31.4 | 0 | 0.0 | |
Intense | 1 | 1.3 | 9 | 4.3 | 24 | 68.6 | 42 | 100 | |
Telomerase | |||||||||
Negative | 28 | 35.4 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | < 0.001 |
Mild | 31 | 39.2 | 8 | 3.8 | 0 | 0.0 | 0 | 0.0 | |
Moderate | 19 | 24.1 | 124 | 59.6 | 8 | 22.9 | 0 | 0.0 | |
Intense | 1 | 1.3 | 75 | 36.1 | 27 | 77.1 | 42 | 100 | |
ROS | |||||||||
Q1 | 38 | 29.5 | 38 | 17.9 | 5 | 17.2 | 17 | 53.1 | < 0.001 |
Q2 | 45 | 34.9 | 37 | 17.5 | 9 | 31.1 | 10 | 31.3 | |
Q3 | 30 | 23.2 | 55 | 25.9 | 12 | 41.4 | 4 | 12.5 | |
Q4 | 16 | 12.4 | 82 | 38.7 | 3 | 10.3 | 1 | 3.1 | |
8-OHdG | |||||||||
Q1 | 63 | 67.7 | 11 | 6.5 | 5 | 19.2 | 0 | 0 | < 0.001 |
Q2 | 23 | 24.7 | 40 | 23.5 | 6 | 23.1 | 12 | 37.5 | |
Q3 | 4 | 4.3 | 67 | 39.4 | 5 | 19.2 | 5 | 15.6 | |
Q4 | 3 | 3.2 | 52 | 30.6 | 10 | 38.5 | 15 | 46.9 | |