Table 1 The main characteristics of cohort and Population based cohort studies of ATM variants on risk of Breast cancer
Authors (years) (country) | Study population | Age | Sample size | Type of variant | Measurement of association | Controlled variables | NOS Score |
|---|---|---|---|---|---|---|---|
Nic Waddell. et al. (15) (2006) (South Australia) | South Australia and Royal Melbourne Hospita | All age | 782 | 7271 T > G (V2424G) | hazard ratio of 6.1 (95% CI: 1.2–30.8) | multiple-case non-BRCA1 and non- BRCA2 breast cancer families | 7 |
Sarah Louise Dombernowsky. et al. (5) (2008) (Denmark) [11] | Danish general population | 10,324 | Ser49Cys | Age Adjusted HR 95% CI 1.0 (0.5–2.2) | Heterozygotes versus Alcohol consumption Smoking habits Reproductive history | 7 | |
Multifactorial Adjusted HR 95% CI 0.8 (0.3–2.0) | |||||||
Ser707Pro | Age Adjusted HR 95% CI 0.60 (0.2–1.5) | ||||||
Multifactorial Adjusted HR 95% CI 0.6 (0.2–1.6) |