Subgroup | Number OR in primary studies | Summery effect size (95% CI) | Between studies | Between subgroups | |||
---|---|---|---|---|---|---|---|
I2 | P heterogeneity | z | Q | P heterogeneity | |||
Adjusted Case Control studies | |||||||
Heterozygosity variants | |||||||
Hetro | 13 | 1.98 (1.22–3.19) | 80% | 0.0001 | 2.78 | 5.03 | 0.0001 |
Hemo | 4 | 1.63 (1.20–2.22) | 0.0% | 0.929 | 2.12 | ||
Hetro/Hemo | 7 | 1.22 (1.01–1.46) | 0.0% | 0.433 | 3.14 | ||
Continent | |||||||
Asia | 2 | 4.21 (0.78–22.88) | 89.5% | 0.0001 | 1.67 | 4.03 | 0.0001 |
America | 3 | 1.55 (1.19–2.01) | 60.4% | 0.001 | 3.22 | ||
European | 2 | 1.24 (0.94–1.64) | 18.5% | 0.297 | 1.49 | ||
Type | |||||||
c.7271 T > G | 2 | 8.94 (4.28–18.67) | 0.0% | 0.789 | 5.83 | ||
D1853V | 2 | 0.43 (0.09–2.07) | 78.6% | 0.031 | 1.05 | ||
S707P | 3 | 1.17 (0.73–1.87) | 49.2% | 0.140 | 0.66 | 4.03 | 0.0001 |
F858L | 2 | 1.43 (1.02–2.00) | 0.0% | 0.943 | 2.10 | ||
IVS38–8 T > C, c.5557G > A | 2 | 1.90 (0.80–4.48) | 48.9% | 0.162 | 1.46 | ||
IVS38–8 T > C | 2 | 3.04 (1.48–6.25) | 0.0% | 0.963 | 3.04 | ||
IVS24-9delT | 2 | 1.70 (1.13–2.57) | 0.0% | 0.922 | 2.54 | ||
5557G > A | 3 | 1.33 (0.89–1.99) | 54.7% | 0.110 | 1.39 | ||
IVS24-9delT, IVS38–8 T > C, | 2 | 1.90 (0.80–4.48) | 48.9% | 0.162 | 1.46 | ||
5557G > A | 2 | 1.90 (0.80–4.48) | 48.9% | 0.162 | 1.46 | ||
IVS24-9delT, IVS38–8 T > C | |||||||
Unadjusted Case Control studies | |||||||
Heterozygosity variants | |||||||
Hetro | 28 | 1.31 (1.05–1.64) | 76.3% | 0.0001 | 2.35 | 3.89 | 0.001 |
Hetro/Hemo | 3 | 3.43 (0.99–11.84) | 90.9% | 0.0001 | 1.95 | ||
Continent | |||||||
Asia | 3 | 5.37 (1.66–17.48) | 86.5% | 0.0001 | 2.79 | ||
America | 2 | 1.58 (1.07–2.33) | 67.8% | 0.0001 | 2.32 | 3.89 | 0.0001 |
European | 4 | 1.08 (0.85–1.38) | 74.8% | 0.0001 | 0.63 | ||
Type | |||||||
c.1066–6 T > G | 8 | 1.69 (0.91–3.14) | 78.1% | 0.0001 | 1.67 | ||
Ser49Cys | 3 | 9.24 (4.78–17.87) | 0.0% | 0.468 | 6.61 | ||
7271 T > G (V2424G) | 2 | 27.97 (5.01–35.07) | 62% | 0.105 | 3.80 | 3.89 | 0.0001 |
IVS38–8 T > C | 6 | 1.22 (0.98–1.51) | 0.0% | 0.874 | 1.78 | ||
D1853N | 6 | 1.22 (0.98–1.51) | 58.9% | 0.032 | 0.67 |