Recent incidence trend of elderly patients with glioblastoma in the United States, 2000–2017

BMC Cancer

Table 2 Trends of glioblastoma incidence in the elderly population: The SEER 18 registry database, 2000–201

Characteristics	Period	APC (95% CI)	P
Overall	2000–2017	0.3 (−0.1, 0.7)	0.111
Gender
Male	2000–2017	0.2 (− 0.2, 0.6)	0.272
Female	2000–2017	0.2 (− 0.4, 0.8)	0.402
Race
Non-Hispanic White	2000–2017	0.6 (0.2, 1.1)	0.013^c
Non-Hispanic Black	2000–2017	0.2 (−0.8, 1.3)	0.648
Hispanic	2000–2017	0.0 (−0.9, 0.8)	0.923
API	2001–2017	0.7 (−0.6, 1.9)	0.266
Age at diagnosis, years
65–69	2000–2017	0.3 (−0.2, 0.8)	0.219
70–74	2000–2017	0.0 (−0.6, 0.6)	0.976
75–79	2000–2017	0.3 (−0.5, 1.0)	0.482
80–84	2000–2017	0.8 (−0.1, 1.7)	0.092
≥85	2000–2017	0.6 (−0.3, 1.4)	0.186
Histologic type
Glioblastoma, NOS	2000–2017	0.3 (−0.1, 0.7)	0.107
Giant cell glioblastoma	2000–2017	−2.3 (−6.1, 1.7)	0.239
Gliosarcoma	2000–2017	1.2 (−1.0, 3.4)	0.264
Tumor location
Supratentorial	2000–2017	0.7 (0.2, 1.3)	0.016^c
Supratentorial^a	2000–2004	5.1 (0.3, 10.2)	0.039^c
Supratentorial^a	2004–2017	0.0 (−0.6, 0.7)	0.899
Frontal	2000–2017	1.7 (1.0, 2.5)	< 0.001^c
Temporal	2000–2017	0.9 (0.3, 1.6)	0.010^c
Parietal	2000–2017	−0.7 (−1.3, 0.0)	0.060
Occipital	2000–2017	−0.4 (−1.7, 0.9)	0.494
Infratentorial	2000–2017	−0.4 (−3.3, 2.5)	0.750
Overlapping/NOS	2000–2017	−0.9 (−1.6, − 0.2)	0.012^c
Tumor size, cm^b
< 4	2004–2015	2.5 (1.4, 3.6)	< 0.001^c
≥4	2004–2015	0.8 (0.0, 1.6)	0.057
Unknown	2004–2015	−4.9 (−6.6, −3.3)	< 0.001^c

Abbreviations: APC annual percentage change, CI confidence interval, API Asian/Pacific Islander, NOS not otherwise specified
^a A statistically significant change in the APC was observed after join-point analysis
^b Data are only documented between 2004 and 2015
^c Statistically significant

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