Covariate | Univariable | Multivariable | ||
---|---|---|---|---|
OR (95 % CI) | p-value | OR (95 % CI) | p-value | |
ANTIDEPRESSANTS | ||||
Index year (per year) | 1.22 (1.07-1.39) | 0.002** | 1.31 (1.11-1.55) | 0.002** |
Female (vs. male) | 2.99 (1.60-5.60) | 0.001** | 3.41 (1.71-6.80) | 0.001** |
Age (per year) | 1.02 (1.00-1.05) | 0.027* | 1.02 (1.00-1.05) | 0.11 |
Income (per 100.000 SEK) | 0.96 (0.76-1.20) | 0.69 | 1.07 (0.83-1.39) | 0.60 |
Higher education (vs. lower education) | 0.94 (0.78-1.15) | 0.56 | 0.97 (0.78-1.21) | 0.78 |
History of depression | 7.61 (3.88-14.94) | <0.001*** | 6.12 (2.96-12.63) | <0.001*** |
Use of antidepressants preoperatively | 14.15 (5.88-34.08), | <0.001*** | ||
Elixhauser comorbidity index (0, 1, 2, >3) | 1.33 (0.96-1.84) | 0.09 | 1.09 (0.75-1.59) | 0.65 |
Functional level (per WHO performance status category) | 0.98 (0.92-1.03) | 0.38 | 0.96 (0.88-1.06) | 0.42 |
Tumour size (6) | 1.08 (0.96-1-21) | 0.22 | 0.92 (0.79-1.07) | 0.30 |
SEDATIVES | ||||
Index year (per year) | 1.13 (0.99-1.29) | 0.07 | 1.12 (0.97-1.30) | 0.14 |
Female (vs. male) | 1.23 (0.66-2.30) | 0.51 | 1.13 (0.58-2.19) | 0.73 |
Age (per year) | 1.02 (1.00-1.04) | 0.09 | 1.02 (0.99-1.04) | 0.24 |
Income (per 100.000 SEK) | 0.87 (0.67-1.13) | 0.30 | 0.90 (0.62-1.22) | 0.49 |
Higher education (vs. lower education) | 0.81 (0.66-1.00) | 0.05 | 0.90 (0.71-1.13) | 0.35 |
History of anxiety and/or sleeping difficulties | 2.58 (1.36-4.90) | 0.004** | 2.14 (1.09-4.20) | 0.027* |
use of sedatives preoperatively | 3.05 (1.60-5.82), | <0.001*** | ||
Elixhauser comorbidity index (0, 1, 2, >3) | 1.37 (0.98-1.92) | 0.07 | 1.17 (0.80-1.70) | 0.41 |
Functional level (per WHO performance status category) | 0.97 (0.91-1.04) | 0.42 | 0.97 (0.89-1.05) | 0.43 |
Tumour size (6) | 1.09 (0.97-1.23) | 0.17 | 1.00 (0.87-1.16) | 0.98 |
ANTI-EPILEPTICS | ||||
Index year (per year) | 1.13 (0.99-1.29) | 0.07 | 1.12 (0.97-1.30) | 0.14 |
Female (vs. male) | 1.23 (0.66-2.30) | 0.51 | 1.13 (0.58-2.19) | 0.73 |
Age (per year) | 1.02 (1.00-1.04) | 0.09 | 1.02 (0.99-1.04) | 0.24 |
Income (per 100.000 SEK) | 0.87 (0.67-1.13) | 0.30 | 0.90 (0.62-1.22) | 0.49 |
Higher education (vs. lower education) | 0.81 (0.66-1.00) | 0.05 | 0.90 (0.71-1.13) | 0.35 |
History of anxiety and/or sleeping difficulties | 2.58 (1.36-4.90) | 0.004** | 2.14 (1.09-4.20) | 0.027* |
use of AED preoperatively | 9.49 (6.07 – 14.85), | <0.001*** | ||
Elixhauser comorbidity index (0, 1, 2, >3) | 1.37 (0.98-1.92) | 0.07 | 1.17 (0.80-1.70) | 0.41 |
Functional level (per WHO performance status category) | 0.97 (0.91-1.04) | 0.42 | 0.97 (0.89-1.05) | 0.43 |
Tumour size (6) | 1.09 (0.97-1.23) | 0.17 | 1.00 (0.87-1.16) | 0.98 |