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Fig. 8 | BMC Cancer

Fig. 8

From: Extracellular vesicles-derived microRNA-222 promotes immune escape via interacting with ATF3 to regulate AKT1 transcription in colorectal cancer

Fig. 8

Mechanistic scheme depicting immune escape of CRC cells via MSC-EVs (Adobe Illustrator CS6, Adobe, San Jose, CA, USA). Secretion of MSC-EVs into CRC cells increased the expression of miR-222 in the cells. miR-222 targeted ATF3 to inhibit its activity, which led to the activation of ATF3-regulated AKT pathway and a subsequent increase in CRC cell malignant phenotype and immune escape

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BMC Cancer

ISSN: 1471-2407

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