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Table 2 Correlation between dynamic contrast-enhanced integrated MR-PET parameters and serum angiogenesis-related biomarkers

From: Assessing tumor angiogenesis using dynamic contrast-enhanced integrated magnetic resonance-positron emission tomography in patients with non-small-cell lung cancer

 

VEGF-A (pg/mL)

Angiogenin (ng/mL)

Angiopoietin-1 (ng/mL)

R2

Slope

p-value*

R2

Slope

p-value*

R2

Slope

p-value*

MTV (cm3)

0.16

2.26

<  0.001†

0.22

1.45

<  0.001†

0.22

0.29

<  0.001†

SUVmax

0.09

12.67

0.010

0.05

5.34

0.049

0.04

0.96

0.078

ADC (10−6 mm2/sec)

0.03

−0.16

0.184

0.08

−0.16

0.015

0.11

−0.04

0.004†

Ktrans (10−3 min−1)

0.14

0.24

0.001†

0.11

0.07

0.004†

0.26

0.04

<  0.001†

kep (10−3 min− 1)

0.31

0.13

<  0.001†

0.20

0.06

<  0.001†

0.21

0.01

<  0.001†

ve (10−3)

< 0.01

0.04

0.845

0.01

−0.11

0.384

0.12

0.07

0.002†

vp (10−3)

0.05

0.81

0.066

< 0.01

0.06

0.790

0.09

0.13

0.008

iAUC60 (10−3)

0.02

0.13

0.221

< 0.01

0.01

0.926

0.20

0.05

<  0.001†

  1. Abbreviations: MR-PET = magnetic resonance-positron emission tomography; VEGF = vascular endothelial growth factor; MTV = metabolic tumor volume; SUVmax = maximum standardized uptake value; kep = reverse reflux rate constant; Ktrans = volume transfer constant; vp = blood plasma volume fraction; ve = extracellular extravascular volume fraction; ADC = apparent diffusion coefficient; iAUC60 = initial area under the time-to-signal intensity curve at 60 s post enhancement
  2. * Significance tested using Pearson’s linear regression analysis
  3. † When Bonferroni correction was applied for multiple comparisons (a total of eight MR-PET derived parameters), p-values < 0.006 were considered statistically significant