Table 5 Predictive factors of toxicities of induction chemotherapy with TPF in patients treated for locally advanced head and neck cancer (multivariate analysis). Toxicity was assessed according to CTCAE classification V4.0
Anemia | Neutropenia | Febrile neutropenia | Infection | Death | |
|---|---|---|---|---|---|
Grade ≥ 3 | Grade ≥ 3 | Grade ≥ 3 | |||
Age | NS | NS | NS | NS | NS |
Female sex | NS | NS | NS | NS | NS |
Alcohol use | NS | NS | NS | NS | NS |
Liver dysfunction | NS | NS | NS | NS | NS |
Hepatic dysmorphia | NS | NS | NS | NS | NS |
Prothrombin rate | 0.049 | NS | NS | NS | NS |
Diabetes | NS | NS | NS | NS | NS |
HBP | NS | NS | NS | NS | NS |
Ischemic heart disease | NS | NS | NS | NS | NS |
Obstructive pulmonary disease | NS | NS | NS | NS | NS |
Obliterative arteriopathy of the lower limbs | NS | NS | NS | NS | NS |
Performance status | NS | NS | NS | NS | NS |
Weight loss before TPF | NS | NS | NS | NS | NS |
Weight loss during TPF | NS | NS | NS | NS | NS |
Enteral feeding during TPF | NS | NS | NS | 0.047 | NS |