Association of ZNF331 and WIF1 methylation in peripheral blood leukocytes with the risk and prognosis of gastric cancer

Table 2 Association between the methylation status of ZNF331 and WIF1 and GC risk

Methylation status		Case (%)	Control (%)	Crude OR(95% CI)	P	OR^a (95% CI)	P	OR^b (95% CI)	P
ZNF331	Hm	162 (43.8)	221 (60.9)	0.500 (0.373–0.672)	< 0.001*	0.585 (0.382–0.896)	0.014*	0.580 (0.375–0.898)	0.015*
ZNF331	Lm	208 (56.2)	142 (39.1)	1.000		1.000		1.000
WIF1	Hm	88 (24.0)	134 (35.7)	0.567 (0.412–0.781)	0.001*	0.715 (0.450–1.137)	0.157	0.714 (0.445–1.146)	0.162
WIF1	Lm	279 (76.0)	241 (64.3)	1.000		1.000		1.000

Lm low methylation, Hm high methylation, CI confidence interval, OR odds ratio, GC gastric cancer
* Statistically significant
^a Adjusted for age, sex, BMI, monthly income, occupation, family history of GC, H. pylori infection, green vegetables, garlic, beef and mutton, freshwater fish, fried food, refrigerated food, egg, food left overnight, alcohol consumption, water, salted food, dairy products and irregular diet
^b Adjusted for propensity score of all variables

ISSN: 1471-2407