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Table 4 Effects of the combination and interaction between environmental factors and ZNF331 methylation status on GC risk

From: Association of ZNF331 and WIF1 methylation in peripheral blood leukocytes with the risk and prognosis of gastric cancer

Environmental factors

ZNF331 methylation status

Hm

Lm

Interactions

ORa (95% CI)

P

ORa (95% CI)

P

ORb (95% CI)

P

Green vegetables (g/week)

 ≥250

0.073 (0.027–0.196)

< 0.001*

0.126 (0.046–0.340)

< 0.001*

3.080 (0.911–10.406)

0.070

 < 250

0.188 (0.058–0.603)

0.005*

1.000

   

Garlic (times/week)

 ≥1

0.138 (0.080–0.238)

< 0.001*

0.352 (0.211–0.586)

< 0.001*

0.680 (0.328–1.411)

0.300

 < 1

0.576 (0.383–0.868)

0.008*

1.000

   
  1. Lm low methylation, Hm high methylation, CI confidence interval, OR odds ratio, GC gastric cancer
  2. * Statistically significant
  3. a Combined effects adjusted for propensity score of age, sex, BMI, occupation, monthly income and family history of GC
  4. b Interactions adjusted for propensity score of age, sex, BMI, occupation, monthly income and family history of GC
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BMC Cancer

ISSN: 1471-2407

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