Table 1 Clinicopathological parameters
Variables | ER-Positive | ER-Negative | ||||
|---|---|---|---|---|---|---|
Age<35 | 35≤Age≤50 | P-value | Age<35 | 35≤Age≤50 | P-value | |
(N = 147) | (N = 901) | (N = 134) | (N = 663) | |||
Year of diagnosis | Â | Â | Â | Â | Â | 0.585 |
 1991–1995 | 1 (0.7) | 3 (0.3) |  | 1 (0.7) | 2 (0.3) |  |
 1996–2000 | 4 (2.7) | 3 (0.3) |  | 1 (0.7) | 8 (1.2) |  |
 2001–2005 | 24 (16.3) | 111 (12.3) |  | 25 (18.7) | 97 (14.6) |  |
 2006–2010 | 90 (61.2) | 557 (61.8) |  | 75 (56.0) | 411 (62.5) |  |
 2011–2013 | 28 (19.0) | 227 (25.2) |  | 32 (23.9) | 145 (23.9) |  |
Histology | Â | Â | 0.696 | Â | Â | 0.924 |
 Ductal | 140 (95.2) | 846 (93.9) |  | 128 (95.5) | 633 (95.5) |  |
 Lobular | 3 (2.0) | 30 (3.3) |  | 0 (0.0) | 2 (0.3) |  |
 Other | 1 (0.7) | 5 (0.6) |  | 2 (1.5) | 8 (1.2) |  |
 Unknown | 3 (2.0) | 20 (2.2) |  | 4 (3.0) | 20 (3.0) |  |
PR | Â | Â | 0.379 | Â | Â | 0.674 |
 Negative | 45 (30.6) | 244 (27.1) |  | 115 (85.8) | 578 (87.2) |  |
 Positive | 102 (69.4) | 656 (72.8) |  | 19 (14.2) | 85 (12.8) |  |
 Unknown | 0 (0.0) | 1 (0.1) |  | 0 (0.0) | 0 (0.0) |  |
HER2 | Â | Â | 0.404 | Â | Â | 0.012 |
 Negative | 106 (73.6) | 674 (75.6) |  | 104 (77.6) | 429 (64.9) |  |
 Positive | 37 (25.7) | 215 (24.1) |  | 29 (21.6) | 218 (33.0) |  |
 Unknown | 4 (2.7) | 12 (1.3) |  | 1 (0.7) | 16 (2.4) |  |
Clinical Tumor size | Â | Â | 1.000 | Â | Â | 0.745 |
 ≤ 2 cm | 3 (2.0) | 20 (2.2) |  | 2 (1.5) | 14 (2.1) |  |
 > 2 cm | 49 (33.3) | 290 (32.2) |  | 51 (38.1) | 210 (31.7) |  |
 Unknown | 95 (64.6) | 591 (65.6) |  | 81 (60.4) | 439 (66.2) |  |
Palpability | Â | Â | 0.175 | Â | Â | 0.160 |
 Nonpalpable | 1 (0.7) | 29 (3.2) |  | 1 (0.7) | 27 (4.1) |  |
 Palpable | 113 (76.9 | 650 (72.1) |  | 95 (70.9) | 459 (69.2) |  |
 Unknown | 33 (22.4) | 222 (24.6) |  | 38 (28.4) | 177 (26.7) |  |
Nucleus grade | Â | Â | 0.110 | Â | Â | 0.102 |
 I | 10 (6.8) | 85 (9.4) |  | 1 (0.7) | 14 (2.1) |  |
 II | 48 (32.7) | 359 (39.8) |  | 28 (20.9) | 106 (16.0) |  |
 III | 54 (36.7) | 271 (30.1) |  | 57 (42.6) | 350 (52.8) |  |
 Unknown | 35 (23.8) | 186 (20.6) |  | 48 (35.8) | 193 (29.1) |  |
Proliferative index | Â | Â | 0.001 | Â | Â | 0.006 |
 Low | 79 (53.7) | 612 (67.9) |  | 19 (14.2) | 184 (27.8) |  |
 High | 52 (35.4) | 210 (23.3) |  | 91 (67.9) | 378 (57.0) |  |
 Unknown | 16 (10.9) | 79 (8.8) |  | 24 (17.9) | 74 (11.2) |  |