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Table 3 Univariate and multivariate analysis for pathologic complete response

From: Response to neoadjuvant chemotherapy based on pathologic complete response in very young patients with ER-positive breast cancer: a large, multicenter, observational study

Variables

ER-Positive (N = 1048)

ER-Negative (N = 797)

Univariate

Multivariate

Univariate

Multivariate

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Age<35 vs. 35≤Age<50

1.17 (0.51–2.67)

0.71

0.41 (0.05–3.19)

0.39

1.92 (1.17–3.13)

0.01

2.54 (1.27–5.08)

0.01

PR-negative vs. –positive

1.87 (1.01–3.47)

0.05

2.00 (0.68–5.88)

0.21

1.60 (0.78–3.27)

0.20

5.45 (1.26–23.61)

0.02

HER2-positive vs. –negative

0.67 (0.33–1.37)

0.28

NI

 

1.33 (0.82–2.16)

0.25

NI

 

Proliferative index: high vs. low

2.30 (1.02–5.20)

0.05

3.45 (1.17–10.15)

0.03

1.00 (0.58–1.74)

0.99

1.22 (0.60–2.46)

0.58

Nonpalpable vs. palpable

3.28 (0.93–11.54)

0.06

1.61 (0.20–13.16)

0.66

2.27 (0.93–5.53)

0.07

3.95 (1.32–11.8)

0.01

  1. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, OR odds ratio, CI confidence interval, NI not included in the model