Fig. 5

Model represents the possible regulation at differential chromatin accessibility regions. a The peaks that gained chromatin accessibility could be due to the transactivation by mutant p53 in combination with other TFs or interaction with chromatin-modifying enzymes, b The peaks that loss chromatin accessibility could be due to the hijacking of TFs from the target regions by mutant p53 or interaction with chromatin-modifying enzymes, c enhancer-mediated gene regulation (which includes events from both (a) and (b)), and d direct gene regulation by binding of mutant p53 to specific DNA structural elements like G-quadruplex