Induction chemotherapy combined with immunotherapy in locally advanced head and neck squamous cell carcinoma

BMC Cancer

Table 4 Univariate and multivariate analysis of prognostic factors for progression free survival

Variables	Univariate	Cox model
Variables	Log-rank	p	HR[95%CI]
Age (< 40 vs ≥40)	0.132	0.324	2.065 [0.786–4.337]
Sex (Male vs female)	0.436
ECOG^# (1vs 0)	0.765
Smoker	< 0.001	0.005	1.778 [1.221–3.998]
Drinker	0.437
Primary site (Hypopharynx vs others)	< 0.001	< 0.001	2.876 [1.675–8.448]
Tumor stage (T4 vs T2 + T3)	< 0.001	< 0.001	2.765 [1.476–7.942]
Neck stage (N+ vs N0)	< 0.001	< 0.001	2.654 [1.664–6.831]
Disease stage (IV vs III)	< 0.001	< 0.001	3.075 [1.448–9.934]
Immunotherapy	0.041	0.014	0.781 [0.667–0.906]
Curative method (CRT vs surgery)	0.023	< 0.001	2.006 [1.478–4.643]

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