Characteristics | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
HR (95% CI) | p Value | HR (95% CI) | p Value | |
Continuous variables | ||||
Age (y) | 1.045 (1.033–1.058) | < 0.001 | 1.042 (1.024–1.060) | < 0.001 |
Time interval (months) | 0.976 (0.972–0.980) | < 0.001 | 0.973 (0.967–0.979) | < 0.001 |
First tumor size (mm) | 1.020 (1.005–1.036) | 0.008 | 1.010 (0.988–1.048) | 0.377 |
Second tumor size (mm) | 1.024 (1.008–1.040) | 0.003 | 1.023 (0.999–1.048) | 0.064 |
Categorical variables | ||||
Sex | 0.016 | 0.001 | ||
Female | 0.782 (0.641–0.956) | 0.634 (0.479–0.838) | ||
Male | Ref. level | Ref. level | ||
Number of primary | 0.482 | |||
Two | 1.126 (0.809–1.568) | |||
Three or more | Ref. level | |||
Tumor site relationship | 0.035 | 0.663 | ||
Ipsilateral | 1.256 (1.016–1.551) | 1.064 (0.805–1.406) | ||
Bilateral | Ref. level | Ref. level | ||
Frist histology | 0.003 | 0.233 | ||
AC | 0.680 (0.524–0.883) | 0.004 | 0.719 (0.492–1.051) | 0.089 |
SCC | 0.933 (0.696–1.252) | 0.645 | 0.807 (0.523–1.243) | 0.330 |
Others | Ref. level | Ref. level | ||
Second histology | 0.008 | 0.332 | ||
AC | 0.701 (0.559–0.878) | 0.002 | 0.887 (0.611–1.286) | 0.526 |
SCC | 0.857 (0.646–1.136) | 0.282 | 0.723 (0.464–1.125) | 0.150 |
Others | Ref. level | Ref. level | ||
Frist grade | 0.048 | 0.285 | ||
Well and moderately | 0.799 (0.639–0.998) | 0.847 (0.624–1.149) | ||
Poorly and undifferentiated | Ref. level | Ref. level | ||
Second grade | 0.004 | 0.256 | ||
Well and moderately | 0.678 (0.522–0.882) | 0.835 (0.613–1.139) | ||
Poorly and undifferentiated | Ref. level | Ref. level | ||
Frist types of surgery | < 0.001 | 0.034 | ||
Lobectomy | 0.278 (0.216–0.357) | < 0.001 | 0.570 (0.328–0.992) | 0.047 |
Sublobectomy | 0.478 (0.367–0.623) | < 0.001 | 0.805 (0.461–1.407) | 0.447 |
No surgery | Ref. level | Ref. level | ||
Second types of surgery | 0.009 | 0.004 | ||
Lobectomy | 0.707 (0.538–0.929) | 0.013 | 0.454 (0.282–0.731) | 0.001 |
Sublobectomy | 0.749 (0.601–0.934) | 0.010 | 0.549 (0.363–0.829) | 0.004 |
No surgery | Ref. level | Ref. level |