Fig. 1

Splicing events in KIRC associated with cancer stemness. a tSNE plot of 605 KIRC samples obtained from TCGA and clustered by PSI value of KASE. Cells are colored-coded according to identified tissue types. b The PSI value of representative KASEs showing the opposite preference between KIRC and adjacent normal tissues. Student’s t-test was used. *: P < 0.05. c The intersection of spliced genes and different expression genes. d Biological processes analysis of KASEs. The significance was indicated by the adjusted p-value (adjusted p-value< 0.05) and showed on the height (the curved y-axis) of the red and blue dots indicates. e Gene set enrichment analysis of the spliced gene signatures in the Molecular Signatures Database (MSigDB) curated gene sets