Table 1 Patient and tumor characteristics of high-and low-grade datasets
SEER Whole | SEER Training | SEER Validation | Chinese Validation | |
|---|---|---|---|---|
Population [cases(%)] | Cohort [cases(%)] | Cohort [cases(%)] | Cohort [cases(%)] | |
High grade Characteristis | ||||
Total | 3476 | 2436 | 1040 | 66 |
Age | ||||
Median (IQR),years: 73 (64–80) | ||||
< =66 | 1128 (32.5) | 803 (33.0) | 325 (31.3) | 22 (33.3) |
67–80 | 1565 (45.0) | 1097 (45.0) | 468 (45.0) | 36 (54.5) |
> 80 | 783 (22.5) | 536 (22.0) | 247 (23.8) | 8 (12.1) |
Sex | ||||
male | 1929 (55.5) | 1353 (55.5) | 576 (55.4) | – |
female | 1547 (44.5) | 1083 (44.5) | 464 (44.6) | – |
Race | ||||
white | 2979 (85.7) | 2074 (85.1) | 905 (87.0) | – |
black | 155 (4.5) | 109 (4.5) | 46 (4.4) | – |
other | 342 (9.8) | 253 (10.4) | 89 (8.6) | – |
Primary_site | ||||
Renal pelvis | 2416 (69.5) | 1690 (69.4) | 726 (69.8) | – |
Ureter | 1060 (30.5) | 746 (30.6) | 314 (30.2) | – |
Grade | ||||
III | 1151 (33.1) | 804 (33.0) | 347 (33.4) | – |
IV | 2325 (66.9) | 1632 (67.0) | 693 (66.6) | – |
Laterity | ||||
left | 1756 (50.5) | 1250 (51.3) | 506 (48.7) | – |
right | 1720 (49.5) | 1186 (48.7) | 534 (51.3) | – |
Tumor_size | ||||
Median (IQR),mm: 40 (25–55) | ||||
< 65 mm | 2809 (80.8) | 1971 (80.9) | 838 (80.6) | 62 (93.9) |
> =65 mm | 667 (19.2) | 465 (19.1) | 202 (19.4) | 4 (6.1) |
Histology | ||||
Transitional | 1822 (52.4) | 1291 (53.0) | 531 (51.1) | 57 (86.4) |
Papillary | 1611 (46.3) | 1116 (45.8) | 495 (47.6) | 8 (12.1) |
0ther | 43 (1.2) | 29 (1.2) | 14 (1.3) | 1 (1.5) |
AJCC Stage | ||||
I | 698 (20.1) | 493 (20.2) | 205 (19.7) | – |
II | 533 (15.3) | 380 (15.6) | 153 (14.7) | – |
III | 1286 (37.0) | 886 (36.4) | 400 (38.5) | – |
IV | 959 (27.6) | 677 (27.8) | 282 (27.1) | – |
T | ||||
T1 | 733 (21.1) | 520 (21.3) | 213 (20.5) | 1 (1.5) |
T2 | 595 (17.1) | 416 (17.1) | 179 (17.2) | 27 (40.9) |
T3 | 1672 (48.1) | 1161 (47.7) | 511 (49.1) | 33 (50.0) |
T4 | 476 (13.7) | 339 (13.9) | 137 (13.2) | 5 (7.6) |
N | ||||
N0 | 2837 (81.6) | 1982 (81.4) | 855 (82.2) | 53 (80.3) |
N1 | 354 (10.2) | 255 (10.5) | 99 (9.5) | 7 (10.6) |
N2 | 285 (8.2) | 199 (8.2) | 86 (8.3) | 6 (9.1) |
M | ||||
M0 | 3214 (92.5) | 2251 (92.4) | 963 (92.6) | 61 (92.4) |
M1 | 262 (7.5) | 185 (7.6) | 77 (7.4) | 5 (7.6) |
Ln_surg | ||||
yes | 1220 (35.1) | 868 (35.6) | 352 (33.8) | 12 (18.1) |
no | 2256 (64.9) | 1568 (64.4) | 688 (66.2) | 54 (81.8) |
Radiation | ||||
yes | 246 (7.1) | 165 (6.8) | 81 (7.8) | 4 (6.1) |
no | 3230 (92.9) | 2271 (93.2) | 959 (92.2) | 62 (93.9) |
Chemotherapy | ||||
yes | 930 (26.8) | 647 (26.6) | 283 (27.2) | 29 (43.9) |
no | 2546 (73.2) | 1789 (73.4) | 757 (72.8) | 37 (56.1) |
Low grade Characteristis | ||||
Total | 673 | 473 | 200 | 33 |
Age | ||||
Median (IQR),years: 69 (61–78) | ||||
<=71 | 378 (56.2) | 271 (57.3) | 107 (53.5) | 18 (54.5) |
> 71 | 295 (43.8) | 202 (42.7) | 93 (46.5) | 15 (45.5) |
– | – | – | – | – |
Sex | ||||
male | 399 (59.3) | 282 (59.6) | 117 (58.5) | – |
female | 274 (40.7) | 191 (40.4) | 83 (41.5) | – |
Race | ||||
white | 591 (87.8) | 419 (88.6) | 172 (86.0) | – |
black | 33 (4.9) | 21 (4.4) | 12 (6.0) | – |
other | 49 (7.3) | 33 (7.0) | 16 (8.0) | – |
Primary_site | ||||
Renal pelvis | 449 (66.7) | 312 (66.0) | 137 (68.5) | – |
Ureter | 224 (33.3) | 161 (34.0) | 63 (31.5) | – |
Grade | ||||
I | 145 (21.5) | 103 (21.8) | 42 (21.0) | – |
II | 528 (78.5) | 370 (78.2) | 158 (79.0) | – |
Laterity | ||||
left | 344 (51.1) | 247 (52.2) | 97 (48.5) | – |
right | 329 (48.9) | 226 (47.8) | 103 (51.5) | – |
Tumor_size | ||||
Median (IQR),mm: 32 (22.5–47.5) | ||||
<=20 mm | 147 (21.8) | 90 (19.0) | 57 (28.5) | – |
> 20 mm | 526 (78.2) | 383 (81.0) | 143 (71.5) | – |
Histology | ||||
Transitional carcinoma | 160 (23.8) | 117 (24.7) | 43 (21.5) | – |
Papillary transitional cell carcinoma | 513 (76.2) | 356 (75.3) | 157 (78.5) | – |
– | – | – | – | – |
AJCC Stage | ||||
I | 386 (57.4) | 271 (57.3) | 115 (57.5) | 12 (36.4) |
II | 112 (16.6) | 79 (16.7) | 33 (16.5) | 9 (27.3) |
III | 129 (19.2) | 90 (19.0) | 39 (19.5) | 10 (30.3) |
IV | 46 (6.8) | 33 (7.0) | 13 (6.5) | 2 (6.0) |
T | ||||
T1 | 392 (58.2) | 275 (58.1) | 117 (58.5) | – |
T2 | 115 (17.1) | 82 (17.3) | 33 (16.5) | – |
T3 | 142 (21.1) | 95 (20.1) | 47 (23.5) | – |
T4 | 24 (3.6) | 21 (4.4) | 3 (1.5) | – |
N | ||||
N0 | 651 (96.7) | 460 (97.3) | 191 (95.5) | – |
N1 | 13 (1.9) | 10 (2.1) | 3 (1.5) | – |
N2 | 9 (1.3) | 3 (0.6) | 6 (3.0) | – |
M | ||||
M0 | 659 (97.9) | 464 (98.1) | 195 (97.5) | – |
M1 | 14 (2.1) | 9 (1.9) | 5 (2.5) | – |
Ln_surg | ||||
yes | 124 (18.4) | 79 (16.7) | 45 (22.5) | – |
no | 549 (81.6) | 394 (83.3) | 155 (77.5) | – |
Radiation | ||||
yes | 9 (1.3) | 8 (1.7) | 1 (0.5) | – |
no | 664 (98.7) | 465 (98.3) | 199 (99.5) | – |
Chemotherapy | ||||
yes | 57 (8.5) | 44 (9.3) | 13 (6.5) | – |
no | 616 (91.5) | 429 (90.7) | 187 (93.5) | – |