Fig. 5

Differentially expressed genes and relevant biological pathways associated to the ATIRE risk score. A Visualization of differentially expressed genes with volcano plot in high-risk patients versus low-risk patients. The expression difference with a log twofold change of 1.5 (outer light gray broken vertical lines) and an adjusted P value of 0.05 (dark broken horizontal line) were labeled. Y axis refers to P values in–log10 scale, X axis refers to the fold change in log 2 scale. B Plot of the KEGG pathway enrichment analysis for ATIRE-related genes based on TCGA data. Y-axis represents pathways; X-axis represents the amount of the ATIRE-related genes enriched in KEGG pathways. The color and size of each bubble represent enrichment significance and the number of ATIRE-related genes enriched in KEGG. C GSEA enrichment plot of hallmarks in high-risk patients versus low-risk patients. KEGG: Kyoto Encyclopedia of Genes and Genomes; GSEA: Gene Set Enrichment Analysis; NES: normalized enrichment score. FDR: false discovery rate