Pathway | Somatic Mutation a | WCH + TCGA | WCH | TCGA | P for heterogeneity | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Odds ratio b | Cases | Controls | Odds ratio | Cases | Controls | Odds ratios | |||
Adrenergic | No mutation | 77 | 75 | Ref | 38 | 49 | Ref | 39 | 26 | Ref | - |
Any mutation | 131 | 133 | 1.16 (0.74, 1.81) | 58 | 47 | 2.01 (1.06, 3.8) | 73 | 86 | 0.66 (0.34, 1.29) | 0.02 | |
TMB | 208 | 208 | 1.07 (0.91, 1.24) | 96 | 96 | 1.28 (1.02, 1.59) | 112 | 112 | 0.89 (0.7, 1.12) | 0.03 | |
Glucocorticoid | No mutation | 122 | 137 | Ref | 55 | 65 | Ref | 67 | 82 | Ref | - |
Any Mutation | 86 | 71 | 1.66 (1.07, 2.58) | 41 | 31 | 1.81 (0.95, 3.44) | 45 | 40 | 1.57 (0.84, 2.95) | 0.76 | |
TMB | 208 | 208 | 1.17 (1.02, 1.35) | 96 | 96 | 1.22 (0.99, 1.51) | 112 | 112 | 1.12 (0.91, 1.38) | 0.57 | |
Dopaminergic | No mutation | 135 | 138 | Ref | 59 | 68 | Ref | 76 | 70 | Ref | - |
Any Mutation | 73 | 70 | 1.07 (0.69, 1.66) | 37 | 28 | 1.84 (0.95, 3.56) | 36 | 42 | 0.7 (0.37, 1.33) | 0.04 | |
TMB | 208 | 208 | 1.02 (0.89, 1.17) | 96 | 96 | 1.2 (0.98, 1.46) | 112 | 112 | 0.88 (0.72, 1.08) | 0.03 | |
Serotonergic | No mutation | 135 | 140 | Ref | 60 | 70 | Ref | 75 | 70 | Ref | - |
Any Mutation | 73 | 68 | 1.04 (0.66, 1.62) | 36 | 26 | 1.74 (0.9, 3.36) | 37 | 42 | 0.61 (0.32, 1.18) | 0.03 | |
TMB | 208 | 208 | 1.02 (0.89, 1.18) | 96 | 96 | 1.2 (0.98, 1.47) | 112 | 112 | 0.85 (0.68, 1.05) | 0.02 | |
Cholinergic | No mutation | 61 | 76 | Ref | 30 | 49 | Ref | 21 | 27 | Ref | - |
Any Mutation | 147 | 132 | 1.59 (1.01, 2.53) | 66 | 47 | 2.75 (1.42, 5.32) | 81 | 85 | 0.87 (0.44, 1.72) | 0.02 | |
TMB | 208 | 208 | 1.14 (0.97, 1.34) | 96 | 96 | 1.33 (1.06, 1.67) | 112 | 112 | 0.95 (0.74, 1.21) | 0.05 |