Outcome | Step# | Overall BC IVW method | ER + BC IVW method | ER- BC IVW method |
|---|
NSNP | OR (95%CI) | P | NSNP | OR (95%CI) | P | NSNP | OR (95%CI) | P |
|---|
AM | 3 | 79 | 1.072 (1.035, 1.110) | 8.78 × 10− 5 | 81 | 1.066 (1.023, 1.111) | 0.0024 | 80 | 1.045 (0.979, 1.115) | 0.1871 |
MA | 1 | 3 | 0.922 (0.840, 1.103) | 0.0919 | 3 | 0.939 (0.840, 1.051) | 0.2739 | 3 | 0.883 (0.745, 1.047) | 0.1518 |
MO | 1 | 12 | 1.042 (1.005, 1.081) | 0.0267 | 12 | 1.022 (0.979, 1.068) | 0.3217 | 12 | 1.089 (1.019, 1.163) | 0.0118 |
- Step#: 1, MR analysis with the all remained SNPs; 2, MR analysis after eliminating MRPRESSO outlier (with P < 0.05); 3, MR analysis after removing all the SNPs (with P < 1.00 in MR-PRESSO test); NSNP, number of single nucleotide polymorphism; MR, Mendelian randomization; IVW: inverse variance weighting; OR, odds ratio; CI, confidence interval; BC: breast cancer; ER + BC: estrogen positive breast cancer; ER- BC: estrogen negative breast cancer; AM: any migraine; MA: migraine with aura; MO: migraine without aura; Bold font: The p-values < 0.05 are statistically significant. The ORs were scaled to a 1-unit increase in log-transformed OR of migraine. P values are for ORs (95% CIs)
