Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study

BMC Cancer

Table 3 Heterogeneity and horizontal pleiotropy analyses results

Outcome	AM		MA		MO
Outcome	P_{(Heterogeneity)}	P_(Pleiotropy)	P_{(Heterogeneity)}	P_(Pleiotropy)	P_{(Heterogeneity)}	P_(Pleiotropy)
Overall BC	0.084	0.846	0.092	0.998	0.347	0.300
ER + BC	0.068	0.728	0.274	0.773	0.545	0.480
ER- BC	0.187	0.750	0.152	0.863	0.499	0.515

ER + BC: BC: breast cancer; ER + BC: estrogen positive breast cancer; ER- BC: estrogen negative breast cancer; AM: ang migraine; MA: migraine with aura; MO: migraine without aura. P_{(Heterogeneity)}: p value of Cochrane’s Q value in heterogeneity test; P_(Pleiotropy): The P value for the intercept in the MR-Egger regression was used present the pleiotropy (p < 0.05)

ISSN: 1471-2407