Fig. 5

DNA damage repair (DDR) alterations are prevalent in Chinese AMPAC patients and associated with prognosis. (A) Distribution of DDR genomic alterations (DDR) in specific pathways. (B) Barplot showing the difference in the TMB value in DDRwt, DDRmt and delDDRmt groups in Chinese AMPAC cohort. (C) Barplot showing the difference in the TMB value between patients without and with any DDR alteration in Chinese AMPAC cohort. (D) Barplot showing the difference in the TMB value in DDRwt, DDRmt and delDDRmt groups in western AMPAC cohort. (E) Barplot showing the difference in the TMB value between patients without and with any DDR alteration in Western AMPAC cohort. Distribution of AMPAC patients with different clinical stages in Chinese (F) and Western AMPAC cohort (G). (H-I) overall survival by DDR alteration status. DDRmt: samples without identified DDR alteration; DDRmt: samples with DDR alterations with unknown function; delDDRmt: samples with deleterious DDR alterations