Table 3 Multivariable analysis of prognostic factors

ECOG PS

  2/3 versus 0/1 (Ref)

2.27

1.25–4.10

0.007

-

-

-

Primary site

  GEJ versus Stomach (Ref)

-

-

-

-

-

-

Weight loss

  Yes versus No (Ref)

1.67

1.21–2.28

0.001

1.46

1.04–2.01

0.030

Peritoneal seeding

  Yes versus No (Ref)

-

-

-

1.76

1.10–2.80

0.019

MSI/MMR status

  MSI-H/dMMR versus others (Ref)

0.23

0.10–0.53

0.001

0.03

0.004–0.21

< 0.001

Serum sodium, mEq/L

  < 135 versus ≥ 135 (Ref)

-

-

-

1.92

1.24–2.96

0.003

Serum albumin, g/dL

  < 3.5 versus ≥ 3.5 (Ref)

-

-

-

1.78

1.19–2.66

0.005

Duration of 2nd line therapy^a

  <median versus ≥ median (Ref)

-

-

-

2.17

1.53–3.08

< 0.001