Variable | Training cohort (n = 397) | Validation cohort (n = 175) | p value | ||||
---|---|---|---|---|---|---|---|
Benign | Malignant | p value | Benign | Malignant | p value | ||
Age, mean ± SD, years | 53.49 ± 12.78 | 45.99 ± 14.63 | <0.001* | 53.59 ± 12.89 | 46.19 ± 14.15 | <0.001* | 0.764 |
Thyroid volume, cm3 | 22.70 ± 29.53 | 11.49 ± 15.37 | <0.001* | 20.58 ± 19.44 | 10.81 ± 13.55 | <0.001* | 0.569 |
Gender | Â | Â | 0.083 | Â | Â | 0.773 | 0.842 |
 Male | 45 (19.6) | 45 (26.9) |  | 26 (24.3) | 15 (22.1) |  |  |
 Female | 185 (80.4) | 122 (73.1) |  | 81 (75.7) | 53 (77.9) |  |  |
Number | Â | Â | <0.001* | Â | Â | <0.001* | 0.586 |
 Unifocal | 47 (20.4) | 80 (47.9) |  | 22 (20.6) | 33 (48.5) |  |  |
 Multifocal | 183 (79.6) | 87 (52.1) |  | 85 (79.4 ) | 35 (51.5) |  |  |
Location | Â | Â | 0.278 | Â | Â | 0.074 | 0.269 |
 Left lobe | 108 (47.0) | 65 (38.9) |  | 60 (56.1) | 27 (39.7) |  |  |
 Right lobe | 113 (49.1) | 95 (56.9) |  | 41 (38.3) | 38 (55.9) |  |  |
 Isthmus | 9 (3.9) | 7 (4.2) |  | 6 (5.6) | 27 (39.7) |  |  |
Size | Â | Â | <0.001* | Â | Â | <0.001* | 0.387 |
 0.5-1 cm | 65 (28.3) | 89 (53.3) |  | 23 (21.5) | 38 (55.9) |  |  |
 1-4 cm | 128 (55.7) | 67 (40.1) |  | 63 (58.9) | 23 (33.8) |  |  |
 ≥4 cm | 37 (16.1) | 11 (6.6) |  | 21 (19.6) | 7 (10.3) |  |  |
Hashimoto’s thyroiditis |  |  | 0.089 |  |  | 0.041* | 0.007* |
 Absent | 192 (83.5) | 128 (76.6) |  | 100 (93.5) | 57 (83.8) |  |  |
 Present | 38 (16.5) | 39 (23.4) |  | 7 (6.5) | 11 (16.2) |  |  |