Table 3 Risk factors for progression free survival (PFS) in glioma patients after surgery

Preoperative Period

 Age (Years at Diagnosis)

1.02 (1.00, 1.04)

0.03^*

1.02 (1.01, 1.03)

3.18 × 10^− 3**

1.01 (1.01, 1.02)

3.91 × 10^− 4***

 Sex male/female

1.72 (1.18, 2.52)

0.01^*

0.99 (0.72, 1.36)

0.96

1.19 (0.99, 1.43)

0.06

 Headache yes/no

1.09 (0.69, 1.71)

0.72

1.24 (0.89, 1.72)

0.20

1.11 (0.93, 1.32)

0.26

 Epilepsy yes/no

0.95 (0.53, 1.69)

0.86

0.93 (0.49, 1.76)

0.82

0.47 (0.15, 1.50)

0.20

 Intracranial Space-Occupying Lesion or Intracranial Tumor yes/no

0.81 (0.39, 1.70)

0.58

0.61 (0.24, 1.52)

0.29

1.34 (0.77, 2.32)

0.30

 Illness Duration (Months)

0.99 (0.97, 1.01)

0.20

0.98 (0.96, 1.00)

0.10

1.00 (0.99, 1.01)

0.48

 Tumor Location (Frontal lobe) yes/no

0.94 (0.62, 1.42)

0.77

0.84 (0.57, 1.22)

0.35

0.91 (0.74, 1.12)

0.37

 Tumor Location (Occipital lobe) yes/no

1.64 (0.48, 5.55)

0.43

1.07 (0.51, 2.23)

0.86

1.18 (0.90, 1.55)

0.23

 Tumor Location (Temporal lobe) yes/no

1.41 (0.91, 2.17)

0.12

1.22 (0.85, 1.74)

0.28

1.15 (0.94, 1.40)

0.17

 Karnofsky Score (%)

0.98 (0.97, 1.00)

0.03^*

1.00 (0.99, 1.01)

0.72

1.00 (0.99, 1.00)

0.48

Postoperative Period

 OLIG2 + yes/no

1.02 (0.58, 1.80)

0.94

0.79 (0.49, 1.28)

0.34

0.78 (0.64, 0.95)

0.01^*

 P53 Gene + yes/no

2.15 (1.47, 3.13)

< 0.0001****

1.96 (1.38, 2.77)

1.43 × 10^− 4***

1.22 (1.02, 1.46)

0.03^*

 IDH1/2 + yes/no

0.51 (0.34, 0.76)

8.90 × 10^− 4***

0.45 (0.32, 0.64)

< 0.0001^****

0.54 (0.39, 0.74)

1.60 × 10^− 4***

 Chemotherapy/Radiotherapy yes/no

1.74 (1.00, 3.04)

0.05

0.63 (0.35, 1.13)

0.12

0.38 (0.29, 0.49)

< 0.0001****

 Karnofsky Score (%)

0.98 (0.97, 0.99)

3.50 × 10^− 4***

0.98 (0.97, 0.99)

8.75 × 10^− 4***

0.99 (0.98, 0.99)

< 0.0001****