Fig. 6

Quantitative analysis of the peri-tumor environment (pTE) in T1-weighted (T1w) magnetic resonance imaging. The panels display: (A) original T1w sequence with tumor segmentation overlaid for three cases labelled 1, 2 and 3, (B) corresponding segmentation of the 5 mm-thick outer margin, depicting the peritumoral region; and (C) a histogram representing the intensity distribution from the peritumoral region, enhanced with a superimposed density curve, for 3 patients with mostly fatty pTE (1), mixed fibroglandular and fatty pTE (2) and mostly fibroglandular pTE (3). The shape of the density curve and the position of the peaks vary in these 3 patients, depending on the relative proportion of fat (high intensity pixels) and fibroglandular tissue (low intensity pixels). pTE: peri-tumor environment, T1w: T1-weighted MRI