Table 3 Univariate analyses of PFS and OS

AFP

Low

Reference

Reference

High

3.419

1.973–5.925

0.000

2.631

1.472–4.703

0.001

Age

< 60

Reference

Reference

≥ 60

0.784

0.523–1.175

0.239

0.911

0.580–1.431

0.686

Gender

Male

Reference

Reference

Female

1.116

0.710–1.756

0.634

0.893

0.543–1.468

0.655

ECOG PS

0–1

Reference

Reference

2–3

1.421

0.958–2.107

0.081

1.264

0.817–1.958

0.293

CPS

< 5

Reference

Reference

≥ 5

0.677

0.427–1.073

0.097

0.687

0.413–1.142

0.148

HER2 status

Negative

Reference

Reference

Positive

0.977

0.564–1.693

0.934

1.121

0.618–2.033

0.708

EBV status

Negative

Reference

Reference

Positive

0.776

0.391–1.542

0.469

0.767

0.353–1.669

0.504

Surgical history

No

Reference

Reference

Yes

0.832

0.540–1.280

0.402

0.759

0.467–1.235

0.267

TNM stage

III

Reference

Reference

IV

2.092

1.335–3.277

0.001

2.291

1.369–3.835

0.002

Treatment regimen

ICI plus chemotherapy

Reference

0.215

Reference

0.529

ICI plus targeted therapy

1.647

0.937–2.893

0.083

1.222

0.646–2.314

0.537

ICI plus chemotherapy and targeted therapy

1.175

0.716–1.930

0.523

1.332

0.788–2.250

0.285

Treatment lines

1–2

Reference

Reference

≥ 3

2.751

1.665–4.546

0.000

1.992

1.150–3.449

0.014

Liver metastases

No

Reference

Reference

Yes

1.279

0.821–1.990

0.276

1.316

0.811–2.135

0.266