Fig. 4
From: EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer
EGR1 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine-induced growth in vivo. (A) Representative photographs of excised tumors from different groups of BALB/C nude mice are shown. (B) Growth curves showing changes in tumor volume in different groups of mice; tumor growth was assessed once a week starting from the injection of gemcitabine (10 mg/kg). (C) The weight of tumors removed from each group of mice. (D) Representative H&E-stained and immunohistochemical images. Scale bar: 50 and 100 μm. (E) Positive Ki-67 staining was assessed using IHC score. Data are expressed as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001