Fig. 4

Anti-tumor efficacy assays in vivo of tumor-bearing mice. (A) In Vivo fluorescence imaging of Cy5.5 labeled aPD-1-PLTM-HMSNs@Sora in H22 tumor-bearing mice. (B) Tumor macroscopic images (1: PBS; 2: Sora; 3: aPD-1; 4: aPD-1 + Sora; 5: aPD-1-PLTM-HMSNs@Sora). (C) Tumor weight. (D) Growth curves of tumors in each group. Error bars represent the SD (n = 5). (E) HE stained tumor slices in each treatment group. (F) Expression of VEGFR2 in tumor tissue. (G) Quantitative analysis of the inhibition by Sora, aPD-1, aPD-1 + Sora, aPD-1-PLTM-HMSNs@Sora on the VEGF-A of tumor (H-score means Histochemistry score). Scale bar, 20 μm. Error bars represent the SD (n = 3)