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Fig. 5 | BMC Cancer

Fig. 5

From: Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Fig. 5

aPD-1-PLTM-HMSNs@Sora triggered a robust, T-cell-mediated anti-tumor immune response. (A) Immunofluorescence of residual tumors showed CD4+ T cells and CD8+ T cells infiltration. Scale bar, 20 μm. (B, C) Quantitative analysis of the number of CD8+ T cells and CD4+ effector T cells of tumor after treatment. (D) Immunofluorescence of residual tumors showed Foxp3+ T cells infiltration. Scale bar, 20 μm (AOD means average optical density). (E) Quantitative analysis of the number of Foxp3+ T cells of tumor after treatment. Error bars represent the SD (n = 3). Statistical significance was calculated via one-way ANOVA with a Tukey post-hoc test. *p < 0.05; **p < 0.01; ***p < 0.001

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BMC Cancer

ISSN: 1471-2407

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