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Table 2 Univariate and multivariate Cox regression analyses of RFS and CSS

From: The impact of squamous cell transformation on the prognosis of patients treated with radical nephroureterectomy

 

Recurrence free survival

Cancer specific survival

univariate

multivariate

univariate

multivariate

Variable

HR

95%CI

P value

HR

95% CI

p-value

HR

95%CI

P value

HR

95% CI

p-value

Tumor type

 UC

referent

  

referent

 

referent

  

referent

  

 UC-SqD

3.34

1.55~7.21

0.0020

1.42

0.48~4.21

0.5250

2.05

0.92~4.53

0.0780

0.78

0.27~2.20

0.6320

 SCC

7.13

2.53~20.15

0.0002

2.93

0.49~17.59

0.2390

3.91

1.41~10.87

0.0090

1.0

0.17~5.76

0.9990

Age

1.01

0.99~1.04

0.4040

   

1.04

1.01~1.06

0.0050

1.03

1.00~1.05

0.0280

BMI

0.91

0.83~1.00

0.0360

1.02

0.91~1.13

0.7870

0.91

0.84~1.00

0.0280

0.94

0.85~1.03

0.1810

Tumor volume

1.01

1.00~1.01

<0.0001

1.00

1.00~1.01

0.3240

1.01

1.00~1.01

0.0010

1.00

1.00~1.01

0.6710

Gross hematuria

0.59

0.33~1.05

0.0750

   

0.69

0.41~1.16

0.1610

   

Flank pain

1.87

1.04~3.38

0.0370

1.13

0.50~2.55

0.7680

2.24

1.33~3.77

0.0020

1.88

0.96~3.68

0.0670

Smoking

1.30

0.70~2.44

0.4070

   

1.06

0.59~1.91

0.8420

   

Uremia

1.06

0.45~2.51

0.8870

   

1.16

0.55~2.44

0.7000

   

pathologic stage

 ≦T2

referent

  

referent

  

referent

  

referent

  

 >T2

8.38

3.31~21.20

<0.0001

4.89

1.37~17.47

0.0150

4.64

2.35~9.18

<0.0001

2.00

0.84~4.80

0.1190

LN stage

 pN0/Nx

referent

  

referent

  

referent

  

referent

  

 pN+

7.52

3.99~14.21

<0.0001

4.12

1.78~9.57

0.0010

9.36

5.40~16.23

<0.0001

6.50

3.22~13.11

<0.001

LVI

5.45

3.07~9.67

<0.0001

2.29

1.10~4.76

0.0270

4.59

2.73~7.72

<0.0001

2.20

1.14~4.26

0.0190

Surgical margin (+)

5.65

2.64~12.12

<0.0001

1.88

0.68~5.25

0.2260

3.61

1.71~7.62

0.0010

1.12

0.43~2.96

0.8140

Adjuvant chemotherapy

2.85

1.60~5.06

0.0004

0.61

0.28~1.34

0.2210

s2.03

1.20~3.42

0.0080

0.63

0.32~1.24

0.1820