Table 2 Compare the diagnostic sensitivity and specificity of methylation based on Ct or ΔCt judgment
Cutoff value | SHOX2 ( +) | RASSF1A ( +) | LungMe® ( +) | |||
|---|---|---|---|---|---|---|
Ct < 32 | Ct < 32 and ΔCt ≤ 9 | Ct < 35 | Ct < 35 and ΔCt ≤ 12 | CtSHOX2 < 32 or CtRASSF1A < 35 | CtSHOX2 < 32 and ΔCtSHOX2 ≤ 9 or CtRASSF1A < 35 and ΔCtRASSF1A ≤ 12 | |
Sensitivity (n = 185) | 88.1% | 78.4% | 48.1% | 45.9% | 94.1% | 87.6% |
Specificity (n = 55) | 83.6% | 94.5% | 87.3% | 96.4% | 72.7% | 90.9% |
consistency (n = 240) | 87.1% | 82.1% | 57.1% | 57.5% | 89.2% | 88.3% |