Table 5 Comparison of the sensitivity and specificity of serum tumor markers, pathology, and methylation detection for different subtypes of lung cancer
Biomarkers | Sencitivity | Specificity | PPV | NPV | |||
|---|---|---|---|---|---|---|---|
LC (total) | LUAC | LUSC | SCLC | Benign | |||
n = 172 | n = 98 | n = 52 | n = 22 | n = 55 | |||
Serum | |||||||
CEA | 48.80% | 59.20% | 30.80% | 45.50% | 74.10% | 85.70% | 31.30% |
SCCA | 26.20% | 10.20% | 61.50% | 13.60% | 81.50% | 81.80% | 26.20% |
CYFRA21-1 | 55.80% | 50.00% | 65.40% | 59.10% | 85.20% | 92.30% | 37.70% |
CEA + SCCA + CYFRA21-1 | 75.00% | 73.50% | 82.70% | 63.60% | 55.60% | 84.30% | 41.10% |
Exfoliated cell BALF + Biopsy | |||||||
Cytology | 30.30% | 29.60% | 28.80% | 36.40% | 100.00% | 100.00% | 29.40% |
LungMe® | 86.00% | 80.60% | 92.30% | 95.50% | 92.70% | 97.40% | 67.60% |
Histology | 60.50% | 55.10% | 71.20% | 59.10% | 100.00% | 100.00% | 49.80% |
Cytology + LungMe® | 91.30% | 86.70% | 98.10% | 95.50% | 92.70% | 97.40% | 76.90% |
Histology + Cytology + LungMe® | 96.50% | 94.90% | 100.00% | 95.50% | 92.70% | 98.20% | 83.90% |