Fig. 8

Cell-cell communication analysis. (A-C) Malignant cell-T-cell interactions through chemokines (A), costimulatory molecules (B), and coinhibitory molecules (C). Circle size and color indicate the P values and expression levels of ligand-receptor molecules, respectively. (D-E) Ligand-receptor connections between malignant cells and T-cell subtypes with high (D) or low (E) PRKAA2 expression. (F) The activities of cytokine pathways in PRKAA2 high-expression malignant cells or liver hepatocellular carcinoma (LIHC) patients positively linked to T-cell markers (r > 0.2 and P < 0.05). (G) Signaling activities of cytokines in malignant cells and T cells with high and low PRKAA2 expression