Table 3 Univariate and multivariate analyses of prognostic factors for recurrence-free survival of TSCC

Age: ≤67 years vs. > 67 years

0.97

(0.40–2.32)

0.936

Sex: female vs. male

0.59

(0.25–1.43)

0.242

Pathological T stage: T1/2 vs. T3/4a

2.14

(0.89–5.17)

0.091

Metastasis of cervical lymph node: Absent vs. Present

3.31

(1.36–8.05)

0.008

3.29

(1.23–8.76)

0.017

TNM stage: I-II vs. III-IV

2.46

(0.98–6.19)

0.056

Tumor size(mm): ≤25 mm vs. > 25 mm

2.07

(0.84–5.06)

0.112

Depth of Invasion(mm): ≤8 mm vs. > 8 mm

2.33

(0.93–5.86)

0.072

Histological differentiation: Mod/Poor vs. Well

0.51

(0.21–1.23)

0.134

Mode of invasion (YK classification): 1–3 vs. 4 C/4D

1.79

(0.73–4.40)

0.201

Visual type of proliferation: Superficial/Exophytic vs. Endophytic

0.93

(0.37–2.34)

0.880

Venous invasion: Negative vs. Positive

1.73

(0.72–4.16)

0.221

Perineural invasion: Negative vs. Positive

2.99

(1.19–7.52)

0.020

2.22

(0.86–5.77)

0.101

Lymph duct invasion: Negative vs. Positive

1.72

(0.63–4.74)

0.293

IgG4 expression: Low vs. High

0.33

(0.13–0.85)

0.022

0.22

(0.07–0.62)

0.005

Foxp3 expression: Low vs. High

0.31

(0.12–0.82)

0.018

0.27

(0.10–0.74)

0.011