Fig. 7

Drug interactions in different concentrations for combination response at 24-h timepoint. A Combinations of 17AAG, HSP90 inhibitor, with other drugs. All drug responses were first plotted in gray using two LDA components and mean KS profile (n = 4) for all concentrations of the specific drug treatment (C1 through C6) was lined as a concentration trace. Filled asterisks represented the lowest dose drug responses and open circles represented the highest dose drug responses. Single treatment of 17AAG (in yellow), two proteasome inhibitors (in green), two DNA inhibitors (in blue), and two HDAC inhibitors (in light brown), and combination treatment of 17AAG with appropriate inhibitors (in black) were shown separately. B Combination of paclitaxel, MT inhibitor, with other drugs. Concentration trace has been made as similarly as (A). Single treatment of paclitaxel (in purple), two proteasome inhibitors (in green), two HSP90 inhibitors (in yellow), and two HDAC inhibitors (in light brown), and combination treatment of paclitaxel with appropriate inhibitors (in black) were shown separately. C Combination of INK128, mTOR inhibitor, with other drugs. Concentration trace has been made as similarly as (A). Single treatment of INK128 (in dark brown), two MT inhibitors (in purple), two HSP90 inhibitors (in yellow), and two HDAC inhibitors (in light brown), and combination treatment of INK128 with appropriate inhibitors (in black) were shown separately