Table 1 Characteristics of patients with breast cancer in actual low and high risk groups
Characteristics | Training cohort (n = 335) | P-value | Validation cohort (n = 221) | P-value | ||
|---|---|---|---|---|---|---|
Low risk (Grade1) (n = 47) | High risk (Grade2/3) (n = 288) | Low risk (Grade1) (n = 28) | High risk (Grade2/3) (n = 193) | |||
Age | Â | Â | 0.265 | Â | Â | 0.975 |
≤ 50 | 23 (48.9%) | 166 (57.6%) |  | 15 (53.6%) | 104 (53.9%) |  |
> 50 | 24 (51.1%) | 122 (42.4%) |  | 13 (46.4%) | 89 (46.1%) |  |
Molecular subtype |  |  | < 0.0001 |  |  | < 0.0001 |
Luminal A | 26 (48.9%) | 58 (20.1%) | Â | 16 (57.1%) | 37 (19.2%) | Â |
Luminal B | 16 (34.0%) | 86 (29.9%) | Â | 5 (17.9%) | 71 (36.8%) | Â |
HER2-enriched | 5 (10.6%) | 73 (25.3%) | Â | 4 (14.3%) | 42 (21.8%) | Â |
Triple-negative | 3 (6.4%) | 71 (24.7%) | Â | 3 (10.7%) | 43 (22.3%) | Â |
Tumor size | Â | Â | 0.015 | Â | Â | 0.03 |
≤ 2 cm | 29 (61.7%) | 123 (42.7%) |  | 16 (57.1%) | 69 (35.8%) |  |
> 2 cm | 18 (32.3%) | 165 (57.3%) |  | 12 (42.9%) | 124 (64.2%) |  |
Nodes metastasis | Â | Â | 0.187 | Â | Â | 0.465 |
0 | 31 (66.0%) | 149 (51.7%) | Â | 16 (57.1%) | 94 (48.7%) | Â |
1–3 | 9 (19.1%) | 73 (25.3%) |  | 7 (25.0%) | 43 (22.3%) |  |
≥ 4 | 7 (14.9%) | 66 (22.9%) |  | 5 (17.9%) | 56 (29.0%) |  |
ER |  |  | < 0.0001 |  |  | 0.096 |
Negative | 8 (17%) | 142 (49.3%) | Â | 7 (25%) | 80 (41.5%) | Â |
Positive | 39 (83%) | 146 (50.7%) | Â | 21 (75%) | 113 (58.5%) | Â |
PR |  |  | < 0.0001 |  |  | 0.036 |
Negative | 12 (25.5%) | 155 (53.8%) | Â | 9 (32.1%) | 103 (53.4%) | Â |
Positive | 35 (74.5%) | 133 (46.2%) | Â | 19 (67.9%) | 90 (46.6%) | Â |
HER2 | Â | Â | 0.242 | Â | Â | 0.321 |
Negative | 34 (72.3%) | 183 (63.5%) | Â | 22 (78.6%) | 134 (69.4%) | Â |
Positive | 13 (27.7%) | 105 (36.5%) | Â | 6 (21.4%) | 59 (30.6%) | Â |
TILs-WG median (IQR) | 10% (5-10%) | 10% (5-20%) | 0.457 | 10% (6.25-15%) | 10% (10-20%) | 0.018 |
TILs-score median (IQR) | 1.335 (0.738-2.10) | 2.194 (1.767–2.704) | < 0.0001 | 1.428 (0.749–2.036) | 2.219 (1.652–2.750) | < 0.0001 |