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Table 2 Univariate and multivariate logistic regression analyses of the association of variables with pathologic grades in the training cohort

From: Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer

Characteristics

Univariate analysis

Multivariate analysis

OR

(95%CI)

P-value

OR

(95%CI)

P-value

Age

        

≤ 50

Reference

       

> 50

0.704

0.38

1.306

0.266

NA

  

NA

Molecular subtype

        

Luminal A

Reference

       

Luminal B

2.131

1.038

4.378

0.039

1.320

0.603

2.892

0.487

HER2-enriched

5.79

2.074

16.164

0.001

3.291

1.121

9.660

0. 030

Triple-negative

9.385

2.683

32.827

< 0.0001

5.644

1.552

20.526

0.009

Tumor size

        

≤ 2 cm

Reference

       

> 2 cm

2.161

1.148

4.069

0.017

NA

  

NA

Nodes metastasis

        

0

Reference

       

1–3

1.688

0.763

3.73

0.196

NA

  

NA

≥ 4

1.962

0.822

4.682

0.129

NA

  

NA

ER

        

Negative

Reference

       

Positive

0.21

0.095

0.467

< 0.0001

NA

  

NA

PR

        

Negative

Reference

       

Positive

0.294

0.147

0.590

0.001

NA

  

NA

HER2

        

Negative

Reference

       

Positive

1.501

0.758

2.970

0.244

NA

  

NA

TILs-WG

1.027

0.997

1.058

0.078

NA

  

NA

TILs-score

2.987

2.019

4.417

< 0.0001

2.577

1.696

3.917

< 0.0001

  1. Abbreviations OR, odds ratio; ER, estrogen receptor; PR, progesterone receptor
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